Assessing the Impact of Real-World Cannabis Products on Driving and Cognition
PI: Thomas Marcotte, PhD
This is a clinical study examining the effects of high-THC concentrates (vaping, dabbing), purchased from licensed dispensaries, on driving and cognitive abilities.
Read more: Assessing the Impact of Real-World Cannabis Products on Driving and Cognition
Sex differences in cannabidiol’s effects on blood pressure in normotensive and hypertensive conditions
PI: Zhi-Ling Guo, MD, PhD
This study aims to determine the influence of sex differences on CBD’s effects on cardiovascular functions.
Evaluating the Impact of perioperative cannabidiol exposure in a preclinical model of orthopaedic implant infections
PI: Nicholas Bernthal, MD
This study will explore CBD as a perioperative analgesic for orthopaedic pain.
Myrcene modulates on CB1 receptor function via enhancement of endocannabinoids
PI: Catherine Cahill, PhD
This study will investigate whether terpenes have analgesic potential and whether they enhance endocannabinoid concentrations in the brain
Read more: Myrcene modulates on CB1 receptor function via enhancement of endocannabinoids
Cannabidiol use during pregnancy: Safety and risk for the developing fetus
PI: Jennifer Thomas, PhD
This study will explore how prenatal exposure to CBD and other cannabinoids affects fetal development.
Read more: Cannabidiol use during pregnancy: Safety and risk for the developing fetus
Cannabis and pathogenic mechanisms influencing Blood Brain Barrier function in HIV
PI: Jennifer Iudicello, PhD
This project will combine a clinical observational study with two preclinical models to investigate whether cannabis can protect people with HIV from blood-brain-barrier damage by reducing inflammation and promoting mitochondrial homeostasis.
Read more: Cannabis and pathogenic mechanisms influencing Blood Brain Barrier function in HIV
The effects and brain mechanisms supporting cannabis-induced chronic low back pain relief
PI: Fadel Zeidan, PhD
This is a clinical study to determine if vaporized cannabis directly reduces evoked chronic low back pain.
Read more: The effects and brain mechanisms supporting cannabis-induced chronic low back pain relief
Contribution of genetic factors to individual differences in anxiety in response to the cannabinoids THC and CBD
PI: Jamie Inman, PhD
This is a preclinical study to investigate genetic susceptibility to adverse and/or beneficial effects on anxiety of acute cannabinoid exposure.
Evaluating the efficacy of cannabidiol for reducing cigarette use
PI: Edythe London, PhD
This is a clinical study to evaluate the efficacy of cannabidiol in reducing cigarette smoking.
Read more: Evaluating the efficacy of cannabidiol for reducing cigarette use
Effects of cannabidiol and tetrahydrocannabinol on the microbiome, endocannabinoids and neuroinflammation in HIV
PI: Ron Ellis, MD, PhD
This study will examine the microbiome and endocannabinoid system in people with HIV and how they relate to neuroinflammation and the blood-brain-barrier.
Antinociceptive effects of phytocannabinoids in a mouse model of sickle cell disease (SCD)
PI: Daniele Piomelli, PhD
This is a preclinical study to investigate antinociceptive effects of THC, CBD, and a combination of THC and CBD on sickle cell disease.
Terpenes as novel analgesics - preclinical study
PI: Catherine Cahill, PhD
This is a preclinical study to investigate whether terpenes can modulate both sensory and affective dimensions of ongoing chronic pain.
Translational studies of cannabis administration, cognition, and the endocannabinoid system in HIV
PI: Arpi Minassian, PhD
This study will utilize a cross-species approach to delineate the effects EC system activation has on HIV-relevant cognitive and motivational domains.
Analgesic, appetite-stimulating, and subjective effects of cannabigerol administered alone and in combination with delta-9-tetrahydrocannabinol
PI: Ziva Cooper, PhD
This clinical trial will examine the effects of combining THC and cannabigerol on pain and other outcomes.
Cannabis, inflammation, and the brain in persons with HIV
PI: Jennifer Iudicello, PhD
This study will examine the effects of chronic cannabis use and the role of the endocannabinoid system on persistent inflammation in people with HIV.
Read more: Cannabis, inflammation, and the brain in persons with HIV
Cannabis effects on antiretroviral therapy pharmacokinetics and neurotoxicity
PI: Scott Letendre, MD
This is a clinical study looking at the intersection of cannabis, HIV, and the Central Nervous System.
Read more: Cannabis effects on antiretroviral therapy pharmacokinetics and neurotoxicity
The Effects of THC on Glucose Metabolism and Endothelial Function in Subjects with Type 2 Diabetes
PI: Jeremy Pettus, MD
This study will seek to determine the effects of THC use on glucose metabolism
Impact of Cannabis Exposure on Gut Barrier Function in Health and Disease
PI: Nicholas DiPatrizio, PhD
This study will examine the impact of cannabis exposure on gut barrier function in metabolic disease and experimental colitis
Read more: Impact of Cannabis Exposure on Gut Barrier Function in Health and Disease
Effects of Cannabidiol (CBD) versus Placebo as an Adjunct to Treatment in Early Psychosis
PI: Kristin Cadenhead, MD
This clinical trial will explore the effectiveness of cannabidiol (CBD), in reducing symptoms and improving cognition in early psychosis. Additionally, this trial will examine the effect of CBD on the biological response to stress, and the effect of CBD on eating behavior induced by antipsychotic medication.
Read more: Effects of Cannabidiol (CBD) versus Placebo as an Adjunct to Treatment in Early Psychosis
Therapeutic Response of Cannabidiol in Rheumatoid Arthritis
PI: Veena Ranganath, MD
The overall goal of this proof-of-principle proposal is to examine the efficacy and safety of CBD treatment as adjunctive to the medical management of Rheumatoid Arthritis (RA) patients with moderate to severe disease activity.
Read more: Therapeutic Response of Cannabidiol in Rheumatoid Arthritis